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Further simulations showed that over a wide range of doxorubicin (050 M), the model can be used to suggest the specific concentration and exposure duration required to deplete cytosolic GSH by 70%, the threshold by which antioxidant defence is impaired, protein binding occurs, and cell death is possible
Hayasaka, S
The approval was granted under the FDAs Commissioners National Priority Voucher pilot programme, which expedites review for priority therapies
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The results demonstrated that ARX-luciferase activity was significantly higher in the ZnPTO-treated group than in the control group, confirming that increased zinc levels enhance ATF4-driven activation of the ARX promoter (Fig
